Author + information
- Patrick Collier,
- Xiaopeng Zhou,
- Zoran Popovic,
- Milind Desai,
- Harry Lever,
- Brian Griffin,
- Carmela Tan,
- E. Rodriguez,
- Scott Flamm and
- Deborah Kwon
Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) enables estimation of scar burden in hypertrophic cardiomyopathy (HCM). However, quantitative methods vary with recent data suggesting that higher semi-automated LGE gray-scale thresholds above the mean signal intensity for the visually normal remote myocardium yield the closest approximation of the extent of LGE identified with visual assessment. We sought to compare CMR gray-scale thresholds versus scar burden as measured by the gold standard namely histological scar.
CMR was performed prior to myectomy in 25 consecutive patients with HCM and LGE values for the basal anteroseptal subendocardium were quantified using +2 to +6 standard deviations (SD) thresholding approaches. Histological scar was quantified in multiple representative slides of myectomy biopsy specimens and was visually scored by two pathologists blinded to the MRI analysis.
LGE values for the basal anteroseptal subendocardium correlated with the amount of histological scar for all thresholds used with relatively stronger correlations found at higher thresholds (R= 0.49, p=0.016 at a threshold of +2SD versus R=0.56, p=0.004 at a threshold of +6SD).
The use of higher semi-automated LGE gray-scale thresholds yields the closest approximation of the extent of LGE identified with histological scar burden in HCM patients.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Imaging: MRI V – CMR in Hypertrophic and Infiltrative Cardiomyopathies
Abstract Category: 19. Imaging: MRI
Presentation Number: 1272-372
- 2013 American College of Cardiology Foundation