Author + information
- Nima Ghasemzadeh,
- Lane Zhang,
- Qunna Li,
- Susan S. Wirtz,
- Abdul Wahab Hritani,
- Saket Kumar,
- Igho Ofotokun,
- Jodie L. Guest,
- W. Robert Taylor,
- Arshed Quyyumi and
- Kreton Mavromatis
HIV+ patients are known to be at risk for coronary artery disease (CAD), but the underlying mechanisms remain unclear. Progenitor cells (PCs) represent endogenous regenerative/repair capacity and their circulating levels are reduced in patients with CAD. We hypothesized that HIV infection is associated with increased risk of CAD due to reduced regenerative capacity measured as lower PCs.
152 age- and gender-matched subjects (38 HIV+, 38 healthy and 76 patients with CAD) were enrolled. HIV+ subjects were aged 45+13 years, 90% male, 89% black, CD4: 622+232 (cells/μl). Flow cytometry was used to enumerate CD34+ cells and their subsets.
HIV+ subjects had significantly lower PCs enumerated as CD34+, CD34+/CD133+/VEGF2R+, and CD34+/VEGF2R+/CXCR4+ cells compared to other groups (Table). HIV+ status was associated with a 44% reduction in CD34+ count (P= 0.01), 55% reduction in CD34+/CD133+/ VEGF2R+ (P=0.001), and 57% reduction in CD34+/VEGF2R++/CXCR4+ cells (P=0.002) after adjustment for CV risk factors and WBC count. HIV+ subjects with <median CD4 counts (577 cells/μl) had lower CD34+/CD133+/VEGF2R+ cells than those with CD4 > median (0.04 vs. 0.16, P=0.008), indicating decreased regenerative capacity with worsening immunity.
PCs are lower in HIV+ drug naïve subjects and are lowest in those with most impaired immunity. This reduced regenerative potential may contribute to the increased risk of CAD in HIV. The effects of anti-retrovirals on PCs need further study.
|PCs (/μl) (Mean+SD)||HIV+ (N=36)||Healthy (N=36)||CAD (N=76)||P value HIV vs. Healthy||P value HIV vs. CAD|
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Chronic CAD: Mechanisms of Repair
Abstract Category: 9. Chronic CAD/Stable Ischemic Heart Disease: Basic
Presentation Number: 1109-69
- 2013 American College of Cardiology Foundation