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Increased epicardial fat volume (EFV) is discussed to be an independent risk factor for coronary artery calcification (CAC). Both EFV and CAC are known to underlay mechanisms of systemic inflammation.
We analyzed EFV and CAC from patients undergoing coronary computed tomography for the detection or for the rule out of coronary artery disease. Traditional risk factors were obtained. A broad range of systemic inflammation markers (eotaxin, G-CSF, GM-CSF, IFN-γ, interleukin (IL) 6, IL 8, IP-10, MCP-1, MIP-1α, MIP-1α, TNF-α, and CRP) were analyzed. In a logistic regression model for binned inflammation markers we included the traditional cardiovascular risk factors, age, gender and obesity. Follow up data was obtained after 1.9 ± 0.5 years.
391 patients (mean age 60 ± 10 years, 272 male gender) were enrolled for a baseline CT. Mean EFV was 116 ± 50 mL. Median CAC was 12 AU (IQR 0; 152). CAC and EFV showed a high significant correlation (p< 0.001). EFV and CAC were significantly associated with risk factors like age, male gender, diabetes mellitus, and hypertension. In multivariate analysis obesity had the highest odds ratio of 5.00 (p< 0.001; CI 95%) for predicting high EFV. Regarding biomarkers, CAC was significantly associated (negatively) with C-CSF and IL13. EFV was significantly correlated (positively) with the biomarkers IP-10 (p= 0.002) and MCP-1 (p= 0.037). IP-10 (values binned, >150 pg/mL) displayed as an independent predictor for high EFV with an odds ratio of 1.66 (p= 0.033). In the follow up group data from 77 patients could be obtained. EFV showed an annualized progression from 6 ml (IQR 3; 9) (p< 0.001), CAC from 6 AU (IQR 0;30) (p< 0.001). The progression of CAC was significantly correlated with the extent of EFV (p< 0.001) while there was no significant correlation between progression of EFV or CAC with the systemic inflammation markers.
EFV and CAC themselves are significantly correlated as well as the progression of CAC with the amount of EFV. While each one, EFV and CAC, show significant correlations with systemic inflammation markers (CAC: C-CSF and IL 13; EFV: MCP-1 and IP-10), the biomarkers show no significant correlation with the progression of CAC and EFV.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Chronic CAD: Inflammation, Thrombosis and Calcification
Abstract Category: 9. Chronic CAD/Stable Ischemic Heart Disease: Basic
Presentation Number: 1153M-62
- 2013 American College of Cardiology Foundation