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Oxidized phospholipids are present on plasminogen (OxPL/PLG) and potentiate fibrinolysis. We recently showed that OxPL/PLG increase following acute myocardial infarction, suggesting that they are involved in atherothrombosis. To derive further insights into the role of OxPL/PLG during PCI, we assessed serial changes in OxPL/PLG in patients with stable angina (SA).
136 patients with SA undergoing PCI with or without stenting were included. Plasma samples were collected before, immediately after, 6 and 24 hours, 3 and 7 days, and 1, 3, and 6 months after the procedure. PLG levels and OxPL/PLG were measured with established assays.
OxPL/PLG declined significantly as mean % change from baseline post PCI (15.0±25.1 % (p<0.001), rebounded and peaked at 3 days 20.4±55.3 % (p<0.001) and slowly returned to baseline by 6 months (trend p<0.0001 by ANOVA, (Fig.1A)). PLG levels showed similar trends (Fig.1B) No significant changes were noted with diagnostic angiography in patients with SA.
Uncomplicated PCI induces acute decreases in OxPL/PLG and PLG. Since OxPL on PLG mediate fibrinolysis, acute reduction in OxPL/PLG and PLG levels suggest induction of a peri-procedural pro-thrombotic milieu that may explain thrombotic complications of PCI.
Moderated Poster Contributions
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Stable Ischemic Heart Disease: Risk Predictors and Biomarkers
Abstract Category: 9. Chronic CAD/Stable Ischemic Heart Disease: Basic
Presentation Number: 1239M-62
- 2013 American College of Cardiology Foundation