Author + information
- Kennosuke Yamashita,
- Myong Hwa Yamamoto,
- Seitarou Ebara,
- Toshitaka Okabe,
- Koichi Hoshimoto,
- Shigeo Saito,
- Tadayuki Yakushiji,
- Naoei Isomura,
- Hiroshi Araki,
- Chiaki Obara and
- Masahiko Ochiai
The aim of this study is to assess the relationship of EFV and plaque vulnerability using a 40MHz IVUS imaging system (iMap-IVUS) in significant coronary stenotic lesion.
We analysed consecutive 130patients (94men and 36women) with suspected coronary artery disease who underwent dual-source CT (DSCT) and cardiac catheterization. Culprit lesions were imaged by iMap-IVUS before stenting. The iMAP-IVUS system analyzed coronary plaques as fibrotic, lipidic, necrotic, or calcified tissue based on the radiofrequency spectrum. Cross-sectional CT cardiac slices (1.0mm thick) from base to apex were traced semiautomatically. Using a 3D workstation, EFV was measured by assigning Hounsfield units ranging from −190 to −30 and was obtained as the sum of fat areas on short axis images.
EFV was 66.8±26.5 (range, 20.8 to 164.4ml). A positive correlation was found between EFV and the percentage of necrotic tissue (r=0.42, p=0.018). However, significant correlation was not observed between EFV and the percentage of fibrotic tissue (r=0.24, p=0.231), lipidic tissue (r=0.32, p=0.137), or calcified tissue (r=0.04, p=0.670). Additionally, multivariate analysis by linear regression (adjustment for age, BMI, LDL cholesterol level) revealed that increased EFV remained as an independent parameter associated with the percentage of necrotic plaque (r=0.37, p=0.024).
Our data demonstrated that increased EFV was associated with the development of coronary atherosclerosis and potentially the most dangerous types of plaques. The measurement of EFV may be a useful marker for detecting the plaque vulnerability.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: New Tests, Targets and Treatments in SIHD
Abstract Category: 10. Chronic CAD/Stable Ischemic Heart Disease: Clinical
Presentation Number: 1240-68
- 2013 American College of Cardiology Foundation