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Plasma high-density lipoprotein (HDL) cholesterol concentration is inversely correlated with coronary artery disease (CAD), and HDL provide cardiovascular protection mainly by promoting reverse cholesterol transport from peripheral tissues. We hypothesized that the cholesterol efflux capacity of HDL could be used to predict coronary artery remodeling as determined by intravascular ultrasound (IVUS).
Fourty consecutive patients with stable CAD who underwent percutaneous coronary intervention under IVUS guidance were enrolled. The cholesterol efflux capacity of HDL was examined with a validated in vitro system. Remodeling patterns at the target lesion were analyzed by IVUS. The remodeling index (RI) was defined as the vessel area at the target lesion divided by that of the averaged reference segments.
The cholesterol efflux capacity of HDL in the positive remodeling group (RI>1.0, n=14) was significantly higher than that in the non-positive remodeling group (RI≤1.0, n=26) (17.1±2.3% vs 15.4±1.9%, P=0.019). The cholesterol efflux capacity of HDL was positively correlated with the RI (R=0.333, P=0.036). Furthermore, logistic regression analysis revealed that the remodeling pattern was significantly correlated with the cholesterol efflux capacity of HDL (p=0.009) among the metabolic factors in addition to high-sensitive C-reactive protein.
To the best of our knowledge, this is the first report that the cholesterol efflux capacity of HDL could be a novel marker for predicting coronary artery remodeling.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: New Tests, Targets and Treatments in SIHD
Abstract Category: 10. Chronic CAD/Stable Ischemic Heart Disease: Clinical
Presentation Number: 1240-69
- 2013 American College of Cardiology Foundation