Author + information
- Laura Franey,
- Amr Abbas,
- Thomas Marwick,
- Micha Maeder,
- David Kaye,
- Antonios Vlahos,
- Walter Serra,
- Karim Al Azizi,
- Nelson Schiller and
- Steven Lester
The ratio of peak tricuspid regurgitation velocity to the time velocity integral of the right ventricular outflow tract (TRV/TVIRVOT) distinguishes elevated versus normal invasive pulmonary vascular resistance (PVRcath). We aim to validate TRV/TVIRVOT as a correlate of PVRcath and compare TRV/TVIRVOT to a modified ratio, TRV2/TVIRVOT, in patients with markedly elevated PVR > 6WU.
Data from 5 international studies comparing non-invasive assessments of PVR using TRV/TVIRVOT (PVRecho1) to PVRcath were collected. Multiple linear regression analyses were generated between PVRcath and both TRV/TVIRVOT and TRV2/TVIRVOT. Bland Altman analysis was performed for PVRcath and PVRecho1 and the new regression equation, TRV2/TVIRVOT (PVRecho2). An ROC was obtained for TRV/TVIRVOT to predict PVR > 6 WU.
150 patients were included. There was better correlation between PVRcath and TRV2/TVIRVOT (r = 0.79, p < 0.0001, Z = −0.01) versus TRV/TVIRVOT (r = 0.76, p < 0.0001, Z = 0.92) (Figure 1), especially with PVR > 6WU. PVRecho2 compared better with PVRcath than PVRecho1 when PVRcath was > 6 WU on Bland Altman (mean 2.06, SD 3.93 versus mean 6.35, SD 3.75) (Figure 2). TRV/TVIRVOT > 0.275 predicted PVRcath > 6WU.
Both TRV/TVIRVOT and TRV2/TVIRVOT identify patients with elevated PVRcath. With PVR > 6 WU, PVRecho2 provides an improved non-invasive estimate of PVRcath compared with PVRecho1.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Pulmonary Hypertension Imaging
Abstract Category: 27. Pulmonary Hypertension
Presentation Number: 1123-152
- 2013 American College of Cardiology Foundation