Author + information
- Keiko Ryo,
- Tetsuari Onishi,
- Josef Marek,
- Mohamed Ahmed,
- Kristina Haugaa,
- Hunter Champion and
- John Gorcsan
Right ventricular (RV) function is critical to patients with pulmonary arterial hypertension (PAH) and assessment of 3-dimensional (3D) RV mechanics is important because of its complex geometry.
To assess novel regional RV mechanics using 3D speckle tracking area strain in PAH compared to normal subjects and invasive hemodynamics.
We studied 54 subjects: 34 PAH patients and 20 normals with 3D imaging (Toshiba Corp.) for RV ejection fraction (EF) and 3D speckle tracking regional strain in the RV free wall and septum. In addition, 26 PAH patients had invasive mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) measured.
Overall, 3D RV strain was significantly reduced with PAH in both the free wall (−48 vs −17%, p<0.01) and the septum (−45 vs −25%, p<0.01), compared with normals. Regional RV strain patterns in PAH patients were reversed with smaller free wall strain than septum strain (−17% vs −25%, p<0.01); whereas normal RV free wall strain was greater than septal strain (−48 vs −45%, p<0.05). Both RV free wall and septal strain highly correlated with 3D RVEF (r=-0.97, −0.85, p<0.001). Interestingly, RV free wall strain in PAH patients correlated with mPAP (r=-0.70, p<0.001) and PVR (r=-0.66, p<0.001).
3D strain imaging demonstrated reversed patterns of free wall and septal RV regional strain in PAH patients compared to normals which correlated with 3D RV EF and invasive PA pressures and has potential for clinical applications.
West, Room 3002
Sunday, March 10, 2013, 8:45 a.m.-9:00 a.m.
Session Title: Pulmonary Hypertension
Abstract Category: 27. Pulmonary Hypertension
Presentation Number: 917-6
- 2013 American College of Cardiology Foundation