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Iron is an important cofactor in oxygen transport and iron availability influences the pulmonary vasoconstrictor response to hypoxia. We aimed to determine the prevalence of iron efficiency in pulmonary hypertension (PHTN) and its relationship with hemodynamics, exercise capacity and NYHA functional class.
Iron deficiency, defined by raised levels of soluble transferring receptor (sTfR) in conjunction with iron parameters were investigated in 125 patients with PHTN. Iron data were related to 6 minute walk distance, hemodynamic measurements from the right heart catheterization, baseline oxygen requirements and NYHA functional class. Patients were also classified according to Dana Point 2008 classification for PHTN.
Iron deficiency was found in significant number of patients (68%) with PHTN. 6 MWD was significantly reduced in iron deficient patients who were on a higher supplemental oxygen and had worse NYHA class compared to iron sufficient patients. Oral iron was administered to 37 patients and majority of them (84%) continued to be iron deficient after a mean duration of 9.5 months. There was no difference in IL-6 levels in either group.
Iron deficiency is present in a majority of patients with PHTN and is associated with lower exercise capacity, worsening of functional class and higher supplemental oxygen requirements. Also a small response to oral iron suggests impaired oral iron absorption and need of intravenous iron replacement in these patients.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Pulmonary Hypertension: Pre-Clinical, Clinical, Biomarkers
Abstract Category: 27. Pulmonary Hypertension
Presentation Number: 1294-145
- 2013 American College of Cardiology Foundation