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Coronary flow reserve (CFR) is known to be reduced in patients with hypertrophic cardiomyopathy (HCM). Decreased CFR, related to microcirculatory dysfunction, is a recognized major mechanism for myocardial ischemia in HCM. We investigated the long-term prognostic value of CFR in asymptomatic patients with non-obstructive HCM.
Thirty-five patients with non-obstructive HCM were investigated. Doppler flow velocity catheters were introduced into the left anterior descending coronary artery to calculate CFR. Eighteen of them showed CFR<2.2(lower CFR) and seventeen of them showed CFR>2.2 (normal CFR). We performed clinical follow-up for median 9.4 years.
There were no significant differences in age, gender, type of left ventricular hypertrophy between two groups. BNP levels in lower CFR were greater than those in normal CFR (p<0.05). During follow-up, eight patients suffered cardiovascular events: 2 cerebral infarction, 2 acute coronary syndrome, 2 hospitalizations for heart failure, 1 implantable cardioverter defibrillator implantation in lower CFR, and 1 cerebral infarction in normal CFR. The incidence of cardio-vascular events was significantly higher in patients with lower CFR than normal CFR (p<0.05).
In patients with non-obstructive HCM, CFR is a promising strong predictor for cardiovascular event.
Moderated Poster Contributions
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: What to Look for When Evaluating Hypertrophic Cardiomyopathy
Abstract Category: 23. Pericardial/Myocardial Disease
Presentation Number: 1295M-156
- 2013 American College of Cardiology Foundation