Author + information
Lipid profile assessment is essential in classifying individuals at risk for cardiovascular disease. However, past smaller studies have provided evidence for seasonal variation in these parameters, which, in turn, may lead to misinterpretation of actual cardiovascular risk.
In a cross-sectional design, we prospectively evaluated lipid profiles of 227,359 individuals who underwent health checkups in primary care centers distributed around five sub-regions of the city of Campinas, Brazil between 2008 and 2010. Assessment of seasonal variability in the prevalence of dyslipidemia was performed by Cosinor analysis using non-linear regression. Year-round variation in frequency of dyslipidemia was evaluated using the Cochran- Armitage test.
Variation amplitude was 7±2 mg/dL for low density lipoprotein cholesterol (LDL-C) (p=0,047), 3.4±0.3 mg/dL for high density lipoprotein cholesterol (HDL-C) (p=0.005), and 12±9 mg/dL for triglycerides (TG) (p=0,058). Plasma LDL-C>130mg/dL was 8% more prevalent during winter than summer, with a superior difference among women and middle-aged adults (p<0.001). HDL- C<40 mg/dL and TG>150 mg/dL were respectively 9% and 5% more prevalent during the summer (p<0.001).
Based on the largest population sample to date, this study confirms the existence of biological rhythms and seasonal variation in lipid profile. This finding must be particularly accounted for in cross-sectional analyses of prevalence of dyslipidemia, investigations of goal achievement for lipid parameters and assessment of relative risk.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Prevention: Risk Assessment and Prevention
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1100-2
- 2013 American College of Cardiology Foundation