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Depression and coronary heart disease(CHD) are leading contributors to disease burden in women. While depression is related to a higher risk of developing CHD, its mechanism is unclear. This study investigates the relation of the severity of depression with the presence of coronary artery calcium(CAC) and low-grade systemic inflammation as measured by serum C-reactive protein(CRP).
Six thousand seven hundred and seventy eight participants (age 62±9 years,52.8% female) from multi-ethnic study of atherosclerosis, a cohort aged 45-84 without clinical CHD at study entry, were studied (BioLINCC/NHLBI approved study-1448). Depression was measured using Center for Epidemiologic Studies Depression Scale(CES:range:0-60). CAC was measured using cardiac computed tomography and was categorized as an Agatston-score of 0 or >0. CRP was measured using standardized techniques, and elevated CRP was defined as>3.0mg/L.
CES depression-score was significantly higher in women as compared to men, especially in those with CAC>0 and elevated CRP(figure) (p15) as compared to those without depression(p0 was significantly higher with MD as compared to those without depression, which was more prominently higher in women as compared to men(p<0.05).
There is a gender-specific direct and independent association between the levels of depressive symptoms, elevated CRP and presence of CAC across multi-ethnic group, which is more prominent in women.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Prevention: Risk Assessment and Prevention
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1100-4
- 2013 American College of Cardiology Foundation