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The association between serum uric acid and cardiovascular (CVD) events has been controversial. However usefulness of a new biomarker is measured in its ability to reclassify CVD events beyond traditional risk factors beyond the mere association. We sought evaluate the association between serum uric acid and CVD mortality and its ability to reclassify risk in a nationally representative population free of clinical CVD.
The study cohort included 11009 adults enrolled as a part of the National Health and Nutrition Examination Survey (NHANES) III free of clinical CVD. Multivariate Cox proportional Hazard analysis was performed to evaluate serum uric acid as a predictor of CVD mortality both as a continuous and categorical variable. After recalibrating the follow-up to 10 years, discrimination of events using traditional CVD risk factors (age, sex, systolic blood pressure, blood pressure medication use, high density lipoprotein, total cholesterol and smoking) with and without serum uric acid was assessed using c-statistics, receiving operating curve characteristics and likelihood ratio test. Net Reclassification Improvement (NRI) index was calculated by comparing regression models incorporating traditional risk factors with and without serum uric acid.
Table 1A and 1B.
Serum uric acid was not predictive of both CVD and CHD deaths. Furthermore, serum uric acid did not add to risk assessment beyond traditional CVD risk factors.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Prevention: Risk Assessment and Prevention
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1100-5
- 2013 American College of Cardiology Foundation