Author + information
- Sean Heffron,
- Amita Singh,
- Johnathan Zagzag,
- Heekoung A. Youn,
- James Underberg,
- George A. Fielding and
- Christine J. Ren
Obesity and the metabolic syndrome (MS) are independent risk factors for cardiovascular disease. Bariatric surgery is employed to reduce weight and associated comorbidities. There is a lack of data on the long-term durability of metabolic changes associated with bariatric surgery, in particular with laparoscopic gastric banding (LAGB).
50 patients with BMI between 30 and 40 underwent LAGB at a single center and were followed annually for 5 years. At follow-up visits, subjects underwent a physical exam and blood sampling. The primary outcome was diagnosis of MS. Secondary outcomes included individual components of the MS and proportions of subjects using oral hyperglycemic or anti-hypertensive agents.
47 patients (45 female, mean age 43.8 years) completed 5 years follow-up. Baseline BMI was 35.1 ± 2.6. Subjects exhibited mean weight loss of 22.3 ± 7.9 kg (22.9 ± 7.4%) at year 1 and maintained this weight loss (19.8 ± 10.2%) through 5 years of follow-up. At baseline, 43% of subjects met NCEP ATPIII criteria for MS. This was reduced to 15% at year 1 and remained decreased throughout 5 years of follow-up (Figure). There were reductions in the proportion of subjects meeting each secondary outcome measure (p<0.001 – p=0.05) throughout 5 years of follow-up.
LAGB produces significant weight loss, resolution of MS by improvement in multiple diagnostic criteria, and reduces use of hyperglycemic and anti-hypertensive agents. These changes persist over 5 years following surgery.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Prevention: Metabolic Syndrome
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1102-14
- 2013 American College of Cardiology Foundation