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Insulin resistance (IR) increases atherogenesis and atherosclerotic plaque instability and further increases risk of myocardial infarction, but its potential association with Post-traumatic stress disorder(PTSD) has not been evaluated. This study assessed the association of PTSD with incidence of IR and metabolic syndrome.
This study included 207,954 Veterans at Southern California and Nevada(age:60±14,93% male, without known coronary artery disease and diabetes mellitus) with and without PTSD who were followed for the median of 2-years. All data were obtained through VA electronic medical records. The incidence of IR(defined as triglyceride over HDL-c ratio≥3.8) and metabolic syndrome(defined based on NCEP ATP III guideline)were assessed.
There were no differences in age, gender, lipid profile, fasting blood sugar and conventional risk factors among those with and without PTSD at baseline(p>0.05). At follow-up, IR was significantly higher in PTSD as compared to non-PTSD(34.8% vs. 19.3%, p=0.00001). Similarly, metabolic syndrome was significantly higher in PTSD as compared to non-PTSD(52.5% vs. 37.3%, p=0.00001). Adjusted incidence rate of IR and metabolic syndrome was 14.2% and 12.07% in PTSD as compared to non-PTSD, respectively(p<0.05). The population risk of IR and metabolic syndrome attributable to PTSD was 49% and 41%,respectively.
PTSD is independently associated with incidence of IR and metabolic syndrome.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Prevention: Metabolic Syndrome
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1102-19
- 2013 American College of Cardiology Foundation