Author + information
- John S. Ho,
- John J. Cannaday,
- Carolyn E. Barlow,
- Dale B. Reinhardt,
- Wendy A. Wade,
- Joe R. Ellis and
- Larry W. Gibbons
The association of vitamin D with cardiovascular events is unclear. Positive studies may have been a result of vitamin D's action on risk factors. We thus evaluated the association of vitamin D with atherosclerosis in those with well controlled risk factors.
Participants underwent coronary artery calcium (CAC) and coronary computed tomographic angiography (CTA). 25-OH vitamin D was also measured. We examined the association between 25-OH vitamin D and CAC scores. We also studied the relation of 25-OH vitamin D with the presence of >70% stenoses, determined by CTA and invasive angiography.
In this study of 1131 patients (mean BP 126/79 mm Hg, mean LDL 95 mg/dl, 7% current smokers, and 6% diabetics), there were 132 (11.7%) 25-OH vitamin D deficient (< 20 ng/ml) and 295 (26.1%) 25-OH vitamin D insufficient (21 ng/ml-29 ng/ml) cases. There was no association between 25-OH vitamin D and CAC scores. The median (interquartile range) CAC score for 25-OH vitamin D deficient, insufficient, and adequate patients was 451 (80,1083), 338 (52,830), and 450 (100,1062), respectively. No relation was noted between 25-OH vitamin D and the 39 cases of severe stenoses. The frequency of severe stenoses in 25-OH vitamin D deficient, insufficient, and adequate patients was 3.8%, 2.0%, and 4.0%, respectively.
25-OH vitamin D is not associated with CAC or severe stenoses in those with well controlled cardiovascular risk factors.
|Median Coronary Artery Calcium (CAC) Score (IQR)||% with SevereCAD|
|25-OH Vitamin D Deficient (< 20 ng/ml)||451 (80,1083)||3.8%|
|25-OH Vitamin D Insufficient (21–29 ng/ml)||338 (52,830)||2.0%|
|25-OH Vitamin D Adequate (> 30 ng/ml)||450 (100,1062)||4.0%|
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Cardiovascular Risk Factors
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1146M-10
- 2013 American College of Cardiology Foundation