Author + information
- Tushar A. Tuliani,
- Abhishek Deshmukh,
- Maithili Shenoy,
- Kaustubh Dabhadkar,
- Sadip Pant,
- Apurva Badheka,
- Diane Levine and
- Luis Afonso
Sub clinical hypothyroidism (SCH) is related to dyslipidemia and atherosclerosis. We explored the effect of SCH on cardiovascular mortality (CVM).
We queried the NHANES-III database (n=7883). We excluded individuals <40 years, TSH levels ≥20 and ≤0.35mIU/L. We defined SCH as individuals with TSH levels between 5-19.99 mIU/L and T4 levels between 5-12 µg/dl. Individuals with TSH between 0.36-4.99 were considered euthyroid. We calculated unadjusted and adjusted hazard ratios over a mean period of 12.3 years.
Prevalence of SCH was 5.34%. In individuals with SCH, 25.18% had CVM versus 16.89% in the euthyroid group. SCH is a strong independent predictor of CVM and ischemic heart disease mortality. (log-rank test p-value<0.001)
SCH predicts CVM in a healthy population.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Risk Factors, from Tooth Loss to Resistin
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1147-20
- 2013 American College of Cardiology Foundation