Author + information
- Arif Khokhar,
- Seth S. Martin,
- Parag H. Joshi,
- Michael Blaha,
- Seth T. Lirette,
- Michael Griswold,
- Krishnaji Kulkarni,
- Herman Taylor and
- Steven Jones
The association between triglyceride-rich remnant lipoprotein cholesterol (RLP-C) with incident myocardial infarction (MI) in African Americans is unknown.
We measured cholesterol in lipoprotein subfractions separated by density gradient ultracentrifugation (Atherotech; Birmingham, AL) in subjects from the Jackson Heart Study, a prospective, observational study of African Americans without cardiovascular disease from the Jackson, Mississippi region. RLP-C was defined as the summation of cholesterol from IDL and VLDL3. We examined associations between lipoproteins, including RLP-C, and adjudicated MI using Cox proportional hazard models adjusting for age, sex, body mass index, education, alcohol, smoking, blood pressure, lipid-lowering therapy and diabetes.
Amongst 4,722 participants (64% women, 53.9±12.8 years) with a median follow up of 5.7 years (max 8.2 years), there were 78 MIs. In multivariable analysis, a one standard deviation increase in RLP-C predicted a 28% increased risk of MI (HR, 1.28; 95% CI, 1.05-1.55), which was primarily driven by IDL-C (Figure 1). In contrast, total cholesterol, LDL-C and non-HDL-C were not significantly associated with MI.
In African Americans from the Jackson Heart Study, RLP-C was most strongly associated with acute MI, whereas associations with traditional lipid measurements were not significant. RLP-C may provide additional information above and beyond the traditional lipid profile.
West, Room 2006
Sunday, March 10, 2013, 8:45 a.m.-9:00 a.m.
Session Title: Prevention: Novel Investigations in Lipidology
Abstract Category: 24. Prevention: Clinical
Presentation Number: 919-6
- 2013 American College of Cardiology Foundation