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This study sought to explore the relationship between Cystatin C (CysC), a novel cardiovascular (CV) biomarker and anthropometric measures of obesity and the influence of this association on mortality (CV, coronary heart disease and all-cause) in a nationally representative population free of CV disease, diabetes mellitus and macroalbuminuria (MA) with creatinine-estimated glomerular filtration rate (eGFR) ≥60 ml/ min/1.73m2.
The study cohort included 4,577 adult participants of the Third National Health and Nutrition Examination Survey (NHANES). Spearman's correlation analysis was performed to ascertain the association between various anthropometric measures and CysC. Formal statistical analyses of the interaction term between anthropometric measures and CysC for outcomes were performed followed by stratified multivariate Cox proportional Hazard analyses.
Figures 1 and Table 1
CysC correlated better with measures of visceral adiposity (waist circumference and waist height ratio) compared to body mass index and appears to be a better predictor of adverse cardiovascular outcomes among those with anthropometric measures in the normal range compared to those with abnormal measures of anthropometry.
West, Room 3004
Sunday, March 10, 2013, 11:15 a.m.-11:30 a.m.
Session Title: Prevention: Clinical and Subclinical Cardiovascular Disease – Predicting Risk in 2013
Abstract Category: 24. Prevention: Clinical
Presentation Number: 928-5
- 2013 American College of Cardiology Foundation