Author + information
- Amita Singh,
- Sean Heffron,
- Jonathan Zagzag,
- Heekoung Youn,
- George Fielding,
- Christine Ren-Fielding and
- James Underberg
Bariatric surgery has become an increasingly utilized treatment for obesity, with short-term trials suggesting improvements in cardiovascular risk factors, including lipid profile. However, the long-term sustainability of these results are less clear.
Fifty patients with BMI of 30-40 who underwent laparoscopic gastric banding (LGB) were followed for five years, with measurement of lipids and anthropometrics at baseline and annual followup.
Of 50 subjects included for analysis, subjects were predominantly women (96%), with a mean age of 43.8 years and mean BMI 35.1. BMI was significantly reduced at five years (mean 27.9+/-4.1, p= 0.003), as was waist circumference (p< 0.001). There was significant improvement in total cholesterol, LDL-C, triglycerides (TG) and HDL-C at year one and two (P<0.001). At five years there was only significant reduction in TG (153.9 vs. 104.9) and HDL-C (56 vs. 70.2). [see figure] Lipid changes did not correlate with % loss BMI or waist circumference. Subjects with the metabolic syndrome (MetS) had greater relative change in TG (−28.6% vs. −34.4%) and HDL-C(+20.9% vs. +34.3%) than those without MetS at five years(P<0.002).
Obese subjects undergoing LGB have significant improvement in lipids, including reduced TG and increased HDL-C, which persist for at least 5 years, with greater benefit in those with MetS. Despite significant sustained weight loss, there was no significant decrease in total cholesterol and LDL-C.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Obesity, Hepatic Steatosis
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1231-3
- 2013 American College of Cardiology Foundation