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Postmenopausal status is associated with increased cardiometabolic risk, although the mechanisms are not fully delineated. Hepatic steatosis appears to be a marker of increased atherosclerotic risk. Whether postmenopausal women have increased prevalence of hepatic steatosis is unclear.
Women aged 30-65 from the Dallas Heart Study (DHS), a multiethnic population-based sample, with information regarding menopausal status were included in the study. Hepatic fat content was measured by magnetic resonance spectroscopy (MRS), and a previously defined cut point (>5.5%) was used to characterize hepatic steatosis. Multivariable adjusted associations between menopausal status and hepatic steatosis were assessed.
Among the 1018 women included in this study, 48% were postmenopausal, and these women were older (55 vs. 37 years) and had increased systolic blood pressure, total cholesterol, triglycerides, fasting glucose and C-reactive protein (CRP) compared with premenopausal women (p<0.0001 for each); no difference was observed with smoking status or body mass index (BMI). Postmenopausal status was associated with an increased prevalence of hepatic steatosis (34% vs. 24%, p<0.0001), as well as an increased absolute hepatic triglyceride content (4.0% vs. 2.9%, p<0.001). This association was maintained across age strata (30-40 and 40-50 yrs). There was also a graded association between time from last menstrual period (LMP) and prevalence of hepatic steatosis when divided into 3 groups (LMP < 2 months, LMP 2-12 months, and LMP>12 months; ptrend<0.001). In multivariable analyses adjusting for age, race, lipids, smoking, blood pressure, diabetes, HOMA-IR, CRP and BMI, postmenopausal status remained independently associated with hepatic steatosis (OR 2.0, 95% CI 1.1-3.6).
Postmenopausal status is independently associated with the prevalence of hepatic steatosis in women. The cardiovascular implications of increased hepatic fat among postmenopausal women require further study.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: Obesity, Hepatic Steatosis
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1231-6
- 2013 American College of Cardiology Foundation