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Regular blood donation might improve flow mediated arterial vasodilation (FMD).
50 adult males without overt CVD were enrolled and donated blood for three times. FMD was measured at baseline, 1 month after each donation. One year after the completion of study, 21 participants, who stopped donating blood, were invited for FMD again. hs-CRP was also measured before, 3 days after and 1 month after first blood donation (n=50), also in participants who accepted the follow up visit (n=21).
Mean age was 29.7±5.6 years. 49/50 were smokers, none had HTN nor DM. Blood donation improved FMD steadily as compared to baseline (mean:10.25% vs 10.44% vs 10.66% vs 10.88%, p=0.039, p=0.003, p=0.001, Figure 1). Furthermore, percent improvement in FMD was negatively correlated with the FMD at baseline (r=-0.360, p=0.01), i.e, those with lower FMD at baseline improved more after regular blood donation. 18 months after the first donation, mean FMD was found to deteriorate by time as compared to baseline in those who stopped blood donation (n=21, 10.2% vs 9.1, p=0.009, Figure 1). In accordance with this, hs-CRP steadily decreased as compared to baseline (mean:2.41 mg/L vs 2.03 mg/L vs 1.95 mg/L, p=0.154, p=0.085). Furthermore, after follow up, it was found to return to baseline level again (mean:2.44 mg/L).
It was shown that regular blood donation improves FMD in healthy adult males. On the other hand, discontinuation of blood donation seems to unshackle progressive decline of FMD.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Prevention: LV, Vascular and Lipoprotein Function
Abstract Category: 24. Prevention: Clinical
Presentation Number: 1233-18
- 2013 American College of Cardiology Foundation