Author + information
- Julio A. Chirinos,
- Ernst R. Rietzschel,
- Marc L. De Buyzere,
- Tom Claessens,
- Dirk De Bacquer,
- Thierry C. Gillebert,
- Patrick Segers,
- Asklepios Investigators
Effective arterial elastance (Ea), the ratio of left ventricular (LV) end-systolic pressure and stroke volume, is increasingly being used to quantify properties of the arterial system and in conjunction with LV end-systolic elastance, is used to assess combined “ventricular-arterial stiffening”. However, theoretical modeling studies indicate that Ea is not prominently affected by arterial stiffness.
We empirically assessed specific arterial determinants of Ea in a population-based sample of 2,368 middle-aged adults without manifest cardiovascular disease. Arterial properties were assessed with Doppler echocardiography and carotid arterial tonometry.
In a multivariable regression model that predicted Ea, systemic vascular resistance (SVR) and heart rate predicted 93.4% of the population variability in Ea, whereas aortic characteristic impedance, total arterial compliance and reflection magnitude contributed only an additional 0.3% of predicted variability. This was true for both men and women and regardless of age. Similarly, after adjustment for SVR and heart rate, Ea had a negligible but significant relationship with carotid-femoral pulse wave velocity (partial R2=0.018; P<0.0001).
In agreement with modeling predictions, our empirical findings demonstrate that Ea is largely a function of systemic vascular resistance and heart rate, rather than total arterial compliance, proximal aortic (pulsatile) impedance or aortic stiffness.
|Standardized coefficient||P value||Partial R2|
|Systemic vascular resistance||0.91||<0.0001||0.92|
|Aortic characteristic impedance||0.02||0.001||0.068|
|Total arterial compliance||−0.02||0.01||0.053|
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Determinants and Modifiers of Arterial Stiffness
Abstract Category: 25. Prevention: Hypertension
Presentation Number: 1234-21
- 2013 American College of Cardiology Foundation