Author + information
- Pyung Chun Oh,
- Seung Hwan Han,
- Jong Goo Seo,
- Soon Yong Suh,
- Kyounghoon Lee,
- Woong Chul Kang,
- Kwang Kon Koh and
- Taehoon Ahn
Aortic stiffness has been demonstrated as an independent risk predictor for development and prognosis of coronary artery disease. We hypothesized that short term rosuvastatin treatment can reduce aortic stiffness in patients with hypercholesterolemia.
Hypercholesterolemic (total cholesterol > 230 mg/dL) patients were prospectively enrolled to rosuvastatin group (10mg/day) and lifestyle modification group. Brachial-ankle pulse wave velocity (baPWV), lipid profiles, hsCRP and metabolic parameters, including fasting blood glucose, insulin and insulin sensitivity measured by quantitative insulin-sensitivity check index (QUICKI), were measured at baseline and after 2 months.
The rosuvastatin group (n=40; age, 50.1±8.9 years) and lifestyle modification group (n=15; age, 50.4±7.8 years) were well balanced with respect to clinical characteristics, baPWV, lipid profiles and metabolic parameters. Rosuvastatin group significantly reduced systolic blood pressure (SBP), diastolic blood pressure (DBP) from baseline (122.5±11.6 vs. 118.0±9.6 mmHg, p=0.005; 77.5±8.7 vs. 73.9±7.6 mmHg, p=0.001), but lifestyle modification didn't. Of interest, there was a significant reduction of baPWV relative to baseline in rosuvastatin group (1390.3±187.6 vs. 1343.1±166.4 cm/sec, p=0.008), but not in lifestyle modification group (1380.4±176.5 vs. 1365.0±200.1 cm/sec, p=0.698). There were significant reductions of total cholesterol and LDL cholesterol in both groups. Rosuvastatin therapy also significantly reduced hsCRP from baseline, but lifestyle modification didn't. Fasting blood glucose, insulin and QUICKI did not differ significantly in both groups. The percent change of baPWV in rosuvastatin group was significantly correlated with the percent change of SBP, DBP or heart rate (r=0.56, p<0.001; r=0.57, p<0.001; r=0.42, p=0.006, respectively) but, not with lipid profiles, metabolic and anti-inflammatory parameters.
Relative short term rosuvastatin treatment in hypercholesterolemic patients can reduce aortic stiffness by favorable hemodynamic changes, independent of lipid lowering, metabolic and anti-inflammatory effects.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Determinants and Modifiers of Arterial Stiffness
Abstract Category: 33. Vascular Medicine: Basic
Presentation Number: 1234-24
- 2013 American College of Cardiology Foundation