Author + information
- Mahboob Alam,
- Salman Bandeali,
- Waleed Kayani,
- Saima A. Shahzad,
- Hani Jneid,
- Yochai Birnbaum,
- Neal Kleiman,
- Joseph Coselli,
- Christie Ballantyne,
- Nasser Lakkis and
- Salim Virani
Short & long term mortality in women undergoing CABG has been evaluated in multiple studies with conflicting results. We conducted meta–analysis of existing literature to evaluate the impact of female sex on mortality in patients undergoing isolated CABG.
A comprehensive literature search (PubMed, Scopus, Ovid till 05/31/2012) identified 20 studies comparing men & women undergoing isolated CABG. All–cause mortality was evaluated at short (post–op and/or 30–days), intermediate (1 yr) & long term (5 yr) follow–up. Review Manager 5.1 was used to conduct meta–analysis using Odds ratio (OR) with random effects model.
A total of 966492 patients [688709 men (71%); 277783 women (29%)] were analyzed. Women were more likely to be older and had significantly greater HTN, DM, HLD, unstable angina, CHF and PAD. Both post–op (OR 1.85, 95% CI 1.66 – 2.05) & 30–day (OR 1.66, 95% CI 1.59 – 1.74) mortality were higher in women. At intermediate and long term follow–up, mortality remained high in women. Women suffered from higher short term mortality in two subgroup analyses including prospective [41,500 patients, OR 1.83, 95% CI 1.59 – 2.12] and propensity score matched studies [11,522 patients, OR 1.36; 95% CI 1.04–1.78] (Table).
Women undergoing isolated CABG experience higher mortality at short, intermediate and long term follow–up compared to men. Mortality remains independently associated with female sex even after propensity score matched analysis of outcomes.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.–10:30 a.m.
Session Title: Cardiac Surgical Outcomes and Quality of Care
Abstract Category: 28. Quality of Care and Outcomes Assessment
Presentation Number: 1289–110
- 2013 American College of Cardiology Foundation