Author + information
- Masataka Nakano,
- Erica Pacheco,
- Ed Acampado,
- Fumiyuki Otsuka,
- Kenichi Sakakura,
- Frank Kolodgie,
- Antonie Lafont and
- Renu Virmani
This study was designed to evaluate by optical coherence tomography (OCT) a novel bioresorbable polymeric stent comprised of poly–lactic acid (PLA) [Arterial Remodeling Technologies, Paris] with a dismantling starting at 3 months and a completed degradation profile of 18 months in a swine model.
The coronary arteries of 82 swine were implanted with either a PLA stent or a BMS. The treated arteries were interrogated in vivo by OCT prior to sacrifice and assessed histologically at 30–, 90–, 180–, 270–, and 365–days. OCT revealed vessel area (EEL) in the PLA group progressively increased over time whereas BMS EEL area did not change, such that at 270 days PLA stent area was significantly larger than BMS. Neointimal area and thickness in PLA stent were greater than BMS at all time points however, lumen area increased as a result of vessel positive remodeling. Polymeric strut integrity on OCT was recognized as i) Preserved; ii) Partially preserved; iii) Dissolved black; or iv) Dissolved white. Table shows the changes of the PLA stent appearance.
Our study demonstrated positive remodeling of coronary vessel treated with a novel PLA stent over time with increased lumen area after 270 days. The OCT characteristics change with time with virtually no intact struts seen at 180 days and a parallel increase in dissolved black signals consistent with continued degradation of the novel PLA polymeric stent.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.–10:45 a.m.
Session Title: Coronary Stents
Abstract Category: 47. TCT@ACC–i2: Coronary Intervention, Devices
Presentation Number: 2101–226
- 2013 American College of Cardiology Foundation