Author + information
- Koji Kato,
- Taishi Yonetsu,
- Haibo Jia,
- Farhad Abtahian,
- Rocco Vergallo,
- Soo–Joong Kim,
- Hang Lee,
- Iris McNulty,
- Stephen Lee,
- Shiro Uemura,
- Yang Soo Jang,
- Seung–Jung Park,
- Kyoichi Mizuno,
- Bo Yu and
- Ik–Kyung Jang
Chronic kidney disease (CKD) promotes the development of atherosclerosis and increases the risk of cardiovascular disease. The aim of the present study was to compare coronary plaque characteristics with and without CKD by Optical Coherence Tomography (OCT).
From the MGH OCT Registry, 463 non–culprit plaques from 287 patients were identified. CKD was defined as estimated glomerular filtration rate (eGFR) < 60ml/min/1.73m2.
402 plaques (250 patients) were in the non–CKD group, 61 plaques (37 patients) were in the CKD group. Compared to non–CKD plaques, plaques with CKD had a wider lipid arc (156.7±34.6 vs. 172.9±37.9) and a larger lipid index (mean lipid arc × lipid length, 1248.4±782.8 vs. 1716.1±1116.2). Fibrous cap thickness was not significantly different between the groups. Calcification (34.8% vs. 50.8%, p=0.022), cholesterol crystals (11.2% vs. 23.0%, p=0.021), and plaque disruption (5.5% vs. 13.1%, p=0.044) were more frequently observed in the CKD group. In multivariate linear regression analysis, a lower eGFR, acute coronary syndrome, and diabetes mellitus were independent risk factors for a larger lipid index (Table).
Compared to non–CKD patients, the patients with CKD had a larger lipid index with a higher prevalence of calcium, cholesterol crystals and plaque disruption. Multivariate linear regression analysis demonstrated that a lower eGFR was an independent risk factor for a larger lipid index.
|Univariate analysis||Multivariate analysis|
|β Coefficient||p-value||β Coefficient||p-value|
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.–4:30 p.m.
Session Title: Complex Patients, Diabetes and Renal Insufficiency
Abstract Category: 38. TCT@ACC–i2: Intravascular Imaging and Physiology
Presentation Number: 2106–231
- 2013 American College of Cardiology Foundation