Author + information
- Usman Baber,
- Jason Kovacic,
- Pedro Moreno,
- Swathi Roy,
- Swapna Sayeneni,
- George Dangas,
- Roxana Mehran,
- Samin Sharma and
- Annapoorna Kini
Women are at increased risk for adverse events after percutaneous coronary intervention (PCI). Chronic kidney disease (CKD) is more common in women and also increases cardiac risk. Whether or not the impact of gender on adverse events after PCI varies by CKD status is unknown.
We studied 15,990 consecutive patients undergoing PCI at the Mount Sinai Medical Center between 1999 and 2009. CKD was defined as estimated glomerular filtration rate <60 ml/min/1.73m2. We compared 2–year mortality rates between men and women stratified by the presence or absence of CKD using the Kaplan–Meier method. Independent associations between gender/CKD groups and mortality were assessed using Cox proportional hazards regression.
CKD was more common in women (n=2022, 36.6%) compared to men (n=2439, 23.3%). Women with CKD were older with a higher frequency of diabetes mellitus and anemia compared to women without CKD or men (n=11529). While mortality at 2 years was higher among women compared to men (12.5% vs 9.5%, p=0.002), differences were larger among those with versus without CKD (Figure 1). After multivariable adjustment, the association between female gender and mortality was larger among those with (HR [95% CI]: 1.52 [1.09–2.10], P=0.01) vs without CKD (HR [95% CI]: 0.86 [0.58–1.26], P=0.44) with evidence of statistical interaction (P=0.03).
Excess risk associated with female gender after PCI varies by CKD status, with a larger impact among those with vs without CKD.
West, Room 2005
Sunday, March 10, 2013, 8:30 a.m.–8:40 a.m.
Session Title: Complicated Patients and Complex PCI
Abstract Category: 43. TCT@ACC–i2: Complex Patients, Diabetes, Renal Insufficiency
Presentation Number: 2904–5
- 2013 American College of Cardiology Foundation