Author + information
- Hiroto Tamaru,
- Kenichi Fujii,
- Masahiko Shibuya,
- Masashi Fukunaga,
- Takahiro Imanaka,
- Kojiro Miki,
- Daizo Kawasaki,
- Motomaru Masutani,
- Mitsumasa Ohyanagi and
- Tohru Masuyama
Although a recent study showed that low tissue backscattering (LTB) seen in optical coherence tomography (OCT) after drug–eluting stents (DES) represents foreign body giant cells and inflammatory cells deposition, its clinical significance is unknown. We evaluate the relationship between intimal tissue characteristics and endothelial function after DES.
Thirty–nine patients who underwent 6–month follow–up OCT after DES in the left–anterior–descending–artery were enrolled. LTB was defined as the majority of neointimal tissue appearing dark or black. The longitudinal extent of LTB was assessed as follows: %LTB, stent length with LTB/entire stent length. Endothelial function was estimated with the coronary vasoreactivity in reference segments of DES in response to acetylcholine (Ach: 10–7&10–6mol/L).
LTB was identified in 13 DES (33%). Vasoconstriction to high–dose Ach was significantly greater in DES with LTB than in DES without LTB (−25.1±23.9% and −3.4±20.1%, p=0.006). There was a linear relationship between %LTB and degree of vasoconstriction to Ach (Figure). However, no correlations were identified between vasoconstriction to Ach and intimal thickness, strut coverage, and number of thrombus and uncovered struts.
The presence and extent of LTB related to endothelial dysfunction after DES implantation. OCT assessment of low backscattered tissue may be used as surrogates for impairment of functional healing after DES.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.–10:30 a.m.
Session Title: Intravascular Imaging: IVUS and OCT
Abstract Category: 38. TCT@ACC–i2: Intravascular Imaging and Physiology
Presentation Number: 2108–242
- 2013 American College of Cardiology Foundation