Author + information
- Masaki Awata,
- Takayuki Ishihara,
- Masashi Fujita,
- Tetsuya Watanabe,
- Osamu iida,
- Shin Okamoto,
- Tomoharu Dohi,
- Kiyonori Nanto,
- Takashi Kanda,
- tatsuya shiraki,
- Takuma Iida,
- Shinsuke Nanto and
- Masaaki Uematsu
Pathological studies have demonstrated subclinical thrombus adhesion to the vessel wall / stent strut is a sign of immature endothelialization. Using angioscopy, we analyzed the relationship between the incidence of thrombus adhesion and morphology of neointimal coverage (NIC).
A total of 154 drug–eluting stents (38 everolius–eluting stents (EES), 46 sirolimus–eluting stents (SES), 35 paclitaxel–eluting stents (PES), 20 zotarolimu–eluting stents (ZES), 15 biolimus–eluting stents) were evaluated by angioscopy approximately 8 months after stent implantation. The degree of neointimal coverage was classified into 2 grades based on whether the stent struts were embedded by the neointima. NIC grade at the site of thrombus adhesion was evaluated.
Thirty–six stents (23.4%) had thrombus adhesion. All thrombi were red, mural, and subclinical, except for 1 white thrombus, which was detected on a SES. All thrombi were observed where stent struts were not embedded by the neointima, except for 2 thrombi, which was found on PESs. In the entire cohort of 154 angioscopic observations, a relationship existed between the neointimal coverage and the thrombi (table, P<0.0001).
Regardless of the stent types, the majority of subclinical thrombi were detected where stent struts were not embedded by the neointima. Given the results from the pathological studies, stent struts that are not embedded by the neointima may indicate immature endotherialization.
Relationship between the incidence of thrombus adhesion and morphology of neointimal coverage
|Struts were not embedded||Struts were embedded||P value|
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.–4:30 p.m.
Session Title: Interventional Aspects of CT and Other Novel Imaging Approaches
Abstract Category: 38. TCT@ACC–i2: Intravascular Imaging and Physiology
Presentation Number: 2112–259
- 2013 American College of Cardiology Foundation