Author + information
- Özgür Akgül,
- Huseyin Uyarel,
- Hamdi Pusuroglu,
- Selahattin Turen,
- Ozgur Surgit,
- Mehmet Gul,
- Mehmet Erturk,
- Umit Bulut,
- Omer Faruk Baycan,
- Mustafa Cetin and
- Nevzat Uslu
Uric acid (UA) is an independent risk factor for the development of coronary heart disease. Serum UA levels have been correlated with all major forms of death from cardiovascular disease, including acute, subacute, and chronic forms of coronary artery disease (CAD), heart failure, and stroke. However, its value in acute ST-segment elevation myocardial infarction (STEMI) remains unclear. The aim of this study was to evaluate the prognostic value of UA in patients with STEMI undergoing primary percutaneous coronary intervention (PCI).
We prospectively enrolled 434 consecutive STEMI patients (mean age 55.4 ± 12.4 years, 341 male, 93 female) undergoing primary PCI. The study population was divided into tertiles based on admission UA values. The high UA group (n=143) was defined as a value in the third tertile (>5.7 mg/dl), and the low UA group (n=291) included those patients with a value in the lower two tertiles (≤5.7 mg/dl). Clinical characteristics, in-hospital and six-month outcomes of primary PCI were analyzed.
Compared to the low UA group, only Killip class >1 at admission was more prevelant in the high UA group (3.4% vs 17.5%, p<0.001, respectively). Higher in-hospital cardiovascular mortality and six-month all-cause mortality rates were observed in the high UA group than lower group (12.6% vs. 1.7%, respectively, p<0.001) and (19.6% vs 4.1%, respectively, p<0.001). In Cox multivariate analysis; a high admission UA value (>5.7 mg/dl) was found to be a powerful independent predictor of six-month all-cause mortality (odds ratio: 5.57, 95% confidence interval: 1.903–16.3, p=0.002).
These results suggest that a high admission UA level was associated with increased in-hospital cardiovascular mortality, and six-month all-cause mortality in patients with STEMI undergoing primary PCI.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: The Blood Tells a Story: Coeptin, Fatty Acid Binding Protein, NT-Pro BNP and More
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1259-216
- 2013 American College of Cardiology Foundation