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Patient specific computational analyses can aid in preoperative planning and long term evaluation of asymmetric deployed Transcatheter Aortic Valves (TAV) in calcified aortic annuli. In this study we developed and validated a preclinical computational tool to predict the performance of TAVs in vivo.
A computational model of a TAV was developed. Mechanical testing and multiphoton microscopy were used to derive stress/strain data and fiber directionality inputs for the computational model (Fig. (a)). The computational model was validated using an in vitro left heart simulator. TAVs were deployed in asymmetric geometries determined from CT images of TAV implant patients. Fiducial markers on the leaflets were tracked using dual–camera photogrammetry to compute strain magnitudes and used to validate predicted strains in the computational model.
Figure 1(c) and (d) show principal strains ranging from −0.03 to 0.27 at peak diastole (Fig. 1 (b)) in the coaptation region in both experimental and computational models. Good agreement was found between experimentally measured and computational predicted strains.
Preliminary data showed the development and validation of a computational model which can be used to investigate leaflet strains in asymmetric deployed TAVs. This can be used as a preoperative planning tool to evaluate optimal placement/orientation of TAVs to reduce peak leaflet strains and thus minimize the occurrence of early fatigue failure.
Moderated Poster Contributions
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.–4:30 p.m.
Session Title: TAVR II: The Devil Is in the Details – Annular Sizing, Post Dilation, Acute Kidney Injury and Conduction Disease
Abstract Category: 32. Valvular Heart Disease: Therapy
Presentation Number: 1242M–87
- 2013 American College of Cardiology Foundation