Author + information
- Jeong Yoon Jang,
- Byung Joo Sun,
- Seungmo Kang,
- Dae–Hee Kim,
- Jong–Min Song,
- Duk–Hyun Kang and
- Jae–Kwan Song
To determine in vivo geometric factors associated with leaflet elongation and adaptation patterns in both prolapsing and non–prolapsing segment, 3D full volume data were obtained during transesophageal echocardiography in 20 healthy subjects and 60 patients with severe mitral regurgitation due to myxomatous degeneration (MD) confined to a single scallop either in anterior (n=14, group A) or posterior leaflet (n=46, group B). A customized software was used to evaluate mitral leaflet surface area (MLSA) and annular area (AA). Compared to controls, patients with MD showed larger total MLSA(12.9±2.3 vs 18.6±3.9 cm2, p<0.01) and AA (8.7±1.3 vs. 11.9±2.5 cm2, p<0.01). In controls, the ratio between anterior to posterior MLSA was 1.4±0.2, which decreased significantly in patients with MD (1.2±0.4, p<0.01). Both anterior (r=0.62, p<0.001) and posterior MLSA (r=0.77, p<0.01) showed a strong positive association with AA in patients with MD. In group B, there was a stronger association (p=0.012) between posterior MLSA and AA (r=0.832, p<0.001) than anterior MLSA and AA (r=0.602, p<0.01). However, in group A, there was no difference in association (p=0.369) between posterior MLSA and AA (r=0.62, p=0.017) than anterior MLSA and AA (r=0.79, p=0.001).
MLSA increase in both prolapsing and non–prolapsing segment proportional to AA is characteristic in MD and a potentially unifying mechanism of leaflet elongation in MD may have a propensity for preferentially affecting posterior leaflet.
Moderated Poster Contributions
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.–10:30 a.m.
Session Title: Valvular Heart Disease: Clinical VII – Mitral Valve
Abstract Category: 31. Valvular Heart Disease: Clinical
Presentation Number: 1285M–81
- 2013 American College of Cardiology Foundation