Author + information
- Ajoy C. Karikkineth,
- Marco Canepa,
- Palchamy Elango,
- James B. Strait,
- Edward G. Lakatta and
- Luigi Ferrucci
Although C–reactive protein has been assessed as a predictor of cardiovascular disease there has been some controversy over the usefulness of C–reactive protein (CRP) in stratification of patients at low and intermediate cardiovascular disease risk.
In participants from the Baltimore Longitudinal Study of Aging (n = 537; age, 26–95 years; median age, 67; 51% male; 57% white) we measured carotid intima medial thickness (cIMT) and assessed CRP and other covariates over a period of up to 8 years (median, 5.0). Linear regression models predicting IMT were adjusted for age, sex, race, systolic and diastolic blood pressures, cholesterol, high density lipoprotein, smoking, body mass index (BMI), waist hip ratio (WHR), glucose, and glomerular filtration rate (based on the Modification of Diet in Renal Disease equation). Log transformation of C reactive protein was performed because of the wide range of values and clustering of values at the lower end. Waist hip ratio (WHR) was categorized using the CDC suggested criteria for males and females; a safe WHR is considered as less than 0.8 in females and less than 0.9 in males, while those with a WHR greater than 1 are considered at increased cardiovascular risk.
In multiple linear regression models, cIMT was significantly associated with age, race, smoking status, gender, systolic and diastolic blood pressures, BMI and WHR (p for all < 0.05). lnclusion of CRP as a covariate did not improve prediction of cIMT beyond that already provided by the BMI and WHR as determined by Akaike Information Criterion (R2 of 0.36 versus 0.37, p = 0.107). Importantly, however, analysis among a cohort with a WHR less than 1 showed that CRP was significantly associated with cIMT (p = 0.033).
In otherwise healthy individuals with low levels of adiposity, CRP has additional predictive power of cIMT levels and may therefore provide useful information for those otherwise thought to be at low levels of cardiovascular risk.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.–10:45 a.m.
Session Title: Atherosclerosis, Inflammation, Biomarkers and Outcomes: What's New?
Abstract Category: 35. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1124–165
- 2013 American College of Cardiology Foundation