Author + information
- Bhavna Balaney,
- Omar Batal,
- Nadeem Kolia,
- Gavin Hickey,
- Zeina Dardari,
- Vivek Reddy,
- Tudor Jovin,
- Maxim Hammer,
- Hunter Champion and
- Mark Schmidhofer
Acute ischemic strokes are often accompanied by cardiac events. The prevalence, associated factors, and implications of elevated troponin I (TnI) in acute ischemic stroke merit further study.
We reviewed our prospective registry of hospitalized patients with acute ischemic stroke from 2009 to 2010. All patients (N=1761) had at least three TnI levels on admission, and 1594 (90%) had transthoracic echocardiography. Primary outcome was death (N=160) or discharge to hospice (N=62).
Positive TnI was present in 309 (17.5%) patients. These patients were significantly more likely to be older, have cardioembolic stroke, atrial fibrillation, higher admission NIH Stroke Scale (NIHSS) score, higher admission systolic blood pressure, lower ejection fraction, and elevated creatinine. Age, NIHSS score, smoking history, history of heart failure or peripheral vascular disease, and serum creatinine were independent predictors of elevated TnI on multivariate analysis (p≤0.01). Primary outcome was significantly higher among patients with positive TnI (27.8% vs 9.4%, p<0.0001, Figure 1), and TnI was independently predictive of prognosis after adjusting for age and NIHSS score by Cox regression analysis (p<0.0001).
TnI is often elevated in acute ischemic stroke and is an important predictor of increased mortality.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.–10:45 a.m.
Session Title: Atherosclerosis, Inflammation, Biomarkers and Outcomes: What's New?
Abstract Category: 35. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1124–166
- 2013 American College of Cardiology Foundation