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It has been recently postulated that not only the quantity but also quality of HDL play an important role in the progression and regression of atherosclerosis. Pitavastatin is a unique statin that possesses both LDL–decreasing and HDL–increasing effects. To clarify whether the HDL increased by pitavastatin exert functional anti–atherosclerotic properties, we examined the qualitative and quantitative changes of HDL during pitavastatin treatment.
A total of 23 dyslipidemic patients were administered with pitavastatin for 4 weeks. Serum lipid profile, paraoxonase (PON1), platelet–activating factor acetylhydolase (PAF–AH), and cholesterol efflux capacity of purified HDL fraction by polyethethylenglycol–precipitation and HDL were evaluated at baseline and after the pitavastatin treatment.
Administration of dyslipidmic patients with 2mg pitavastatin resulted in a 40% decrease in serum LDL–C levels (P<0.01) and a 9.5% increase in HDL–C levels (P<0.05). Cholesterol efflux capacity of purified HDL fraction was positively correlated with serum HDL–C levels, and pitavastatin–induced increase in HDL–C levels is concomitant with the increase in cholesterol efflux capacity of HDL. Activity of HDL–associated PON1 (paraoxonase and arylesterase) post–pitavastatin treatment was increased by 10% (P<0.05) and by 14% (P<0.05), respectively, while HDL–associated PAF–AH activity was not affected by pitavastatin. Furthermore, the pitavastatin treatment increased size and content of phospholipids in HDL particles, which may enhance HDL efflux capacity.
Besides decreasing serum LDL–C levels, pitavastatin elevates serum HDL–C levels and modulates the size, composition and levels of HDL–associated enzymes, but as a whole, increases HDL particles with preserved anti–atherosclerotic properties.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.–10:45 a.m.
Session Title: Vascular Medicine Basic: Atherogenesis
Abstract Category: 33. Vascular Medicine: Basic
Presentation Number: 1125M–168
- 2013 American College of Cardiology Foundation