Author + information
- Andrew David Wisneski,
- Aart Mookhoek,
- Heide Kuang,
- Kiyoaki Takabe,
- Julius M. Guccione,
- Michael Hope,
- Liang Ge and
- Elaine Tseng
Rupture/dissection of ascending thoracic aortic aneurysms (aTAA) can be a lethal cardiovascular emergency. Aneurysm peak wall stress may be a better predictor of rupture risk than diameter; however, in vivo models have never been validated. The goal of this study was to create the first patient–specific computational models of aTAAs associated with bicuspid vs. tricuspid aortic valve using surgical specimens to accurately determine wall stress magnitudes.
High–resolution micro–computed tomography of aTAA surgical specimen was used to construct zero–stress geometry. Bi–axial stretch testing of aTAAs provided stress–strain data to describe aneurysm mechanical properties. Finite element analyses were performed with LS–DYNA finite element software.
Pockets of elevated wall stress were seen in the anatomic left and right regions of the bicuspid aTAA, and in the left face of the inner lumen of the tricuspid aTAA (Figure 1). For the bicuspid aTAA model, mean and peak systolic wall stresses were 125.6 and 623.5kPa, respectively compared to 168.3 and 549.8kPa for the tricuspid aTAA, respectively.
Aneurysm wall stress magnitudes were relatively similar for these two particular patients. Regions of maximal wall stress may indicate sites more prone to rupture. Patient–specific finite element models of surgical aTAAs are critical to validate in vivo–derived models and understand the relationship between wall stress and rupture risk.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.–4:30 p.m.
Session Title: Basic Science Underpinnings of Vascular Disease
Abstract Category: 33. Vascular Medicine: Basic
Presentation Number: 1166–165
- 2013 American College of Cardiology Foundation