Author + information
- Binita Shah,
- Caron Rockman,
- Jaclyn Chesner,
- Yu Guo,
- Arthur Schwartzbard,
- Howard Weintraub,
- Mark Adelman,
- Thomas Riles and
- Jeffrey Berger
The prevalence of vascular disease in different locations (lower extremity peripheral artery disease [PAD], carotid artery stenosis [CAS], abdominal aortic aneurysm [AAA]) in an unselected population with and without diabetes mellitus (DM) is not clearly defined.
The prevalence of vascular disease was evaluated in 3,389,369 participants of the Life Line Screening survey between 2003 and 2008. PAD was defined as ankle brachial index <0.90, CAS as stenosis >50% on duplex ultrasound or history of revascularization, and AAA as infrarenal aortic diameter of > 3cm on ultrasound or history of repair. Odds ratio (OR) [95% confidence intervals] to examine the strength of association between DM and the prevalence of vascular disease was assessed using logistic regression model.
Prevalence of PAD (10.5% v 5.5%, p<0.0001), CAS (10.9% v 5.0%, p<0.0001), and AAA (2.6% v 1.9%, p<0.0001) are significantly higher in participants with compared to those without DM. After multivariate adjustment for demographics and clinical risk factors, DM is associated with increased odds of PAD (OR 1.48 [1.46–1.5]) and CAS (1.54 [1.52–1.57]), but decreased odds of AAA (0.86 [0.84–0.88]). The association between DM and vascular disease severity is shown in Table 1.
In a large contemporary survey, DM is associated with a higher prevalence and severity of PAD and CAS, but a lower association is demonstrated with AAA. Future studies to explore this difference in vascular subtype are needed.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.–4:30 p.m.
Session Title: Classic and Novel Cardiovascular Risk Predictors and Impact
Abstract Category: 35. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1167M–169
- 2013 American College of Cardiology Foundation