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Anemia with iron deficiency correlates with increased mortality for AMI. However, there few studies focused on the association with iron deficiency and clinical outcomes after successful PCI in nonanemic patients with ST-segment elevation AMI (STEMI). This study investigated the effects of serum iron in nonanemic patients with STEMI after primary PCI.
We evaluated 352 consecutive patients with STEMI who underwent successful PCI within 24 hours after onset of symptoms. Patients were stratified into two groups by admission iron (<70mg/dl or not). Patient characteristics, CRP levels on admission, complete (≥50%) STR, in-hospital death, LVEF and plasma BNP levels two weeks after reperfusion were compared between them.
Patientswith low iron (48%), compared to those with normal iron, were older (68±12 versus 63±13yrs, p<0.001), more frequently had women (36 versus 17%, p<0.001), time to reperfusion (6±6 versus 5±4hrs, p=0.03), CRP level (31 versus 12%, p<0.001) and Killip class (≥II) (30 versus 20%, p=0.04), and less frequently had dyslipidemia (54 versus 65%, p=0.03), and had lower complete STR (58 versus 72%, p=0.005), higher plasma BNP level (286±315 versus 184±227pg/ml, p=0.001), and in-hospital death (6.5 versus 1.6%, p=0.03). There was no significant difference in LVEF (54±13 versus 57±12%) between them. In age, women, dyslipidemia, advanced Killip class, CRP level, time to reperfusion, and low iron, advanced Killip class (p=0.04) is the strongest predictor of in-hospital death.
Iron deficiency on admission is associated elevated CRP level and advanced Killip stage, and predicts poor outcomes after primary PCI in nonanemic patients with STEMI.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Acute Coronary Syndromes: Clinical Outcomes
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1299-179
- 2013 American College of Cardiology Foundation