Author + information
- Nicolas F. Meneveau,
- Fiona Ecarnot,
- Youssef El Omri,
- Romain Chopard,
- Marie–France Seronde,
- Sebastien Janin,
- Philoktimon Plastaras,
- Yvette Bernard and
- Francois Schiele
We investigated whether the “Bleeding Academic Research Consortium” (BARC) classification is applicable in the context of pulmonary embolism (PE), where no standard bleeding definition exists.
Prospective, single–center registry of patients (pts) with confirmed PE. We excluded BARC type 1 or 4 bleeds, considered not to be applicable to the context of PE. BARC type 2 bleeds were defined as any overt bleed requiring non–surgical or medical care, or leading to hospitalization. Type 3 bleeds were defined as drop of >3g/dL in hemoglobin, any transfusion, tamponnade, intracranial hemorrhage, or bleed requiring surgical intervention. Type 5 bleeds were defined as any fatal bleed.
From 2007–2011, 666 pts with confirmed PE were included; average age 66±18 years; 52% women; 25% low–risk, 61% intermediate–risk and 14% high–risk PE. Thrombolysis was given in 167(25%). Sixty pts (9%) experienced bleeding (n=13, 43, 4 for BARC types 2, 3 and 5 respectively). Main in–hospital events are shown in table. Independent predictors of in–hospital death were cardiogenic shock (OR 12.6 [4.8–20.8]); chronic obstructive pulmonary disease (OR 5.27 [2.25–8.43]); acute RV dysfunction (OR 2.98 [1.25–6.96]) and any bleed (BARC 2,3,5) (OR 3.15 [1.34–7.37]).
Our data suggest that the BARC classification can be applied to pts with acute PE and that in this population, bleeding events are associated with unfavourable in–hospital outcome.
|BARC type 2 (A)||BARC type 3/5 (B)||No bleed (n=606) (C)||p (A) vs (C)||p (A) vs (B)|
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.–10:30 a.m.
Session Title: Venous Thrombosis and Pulmonary Embolism
Abstract Category: 36. Vascular Medicine: Venous Disease
Presentation Number: 1296–159
- 2013 American College of Cardiology Foundation