Author + information
- Constantina Masoura,
- Konstantinos Aznaouridis,
- Pitsavos Christos,
- Skoumas Ioannis,
- Vlachopoulos Charalambos,
- Psarros Konstantinos and
- Christodoulos Stefanadis
Familial hypercholesterolemia (FH) is associated with increased cardiovascular risk. We evaluated the effect of FH on intima–media thickness of the femoral artery (fIMT), which is a measure of subclinical atherosclerosis.
We meta–analyzed case–control studies, reporting fIMT in untreated FH patients and in normocholesterolemic controls of similar age. For each eligible study we calculated the mean difference (MD) with 95% confidence intervals (CIs) for fIMT (FH minus controls). A random–effects model was used to calculate pooled MDs. To estimate the contribution of continuous study moderators (age, cholesterol levels) on our estimates, we ran meta–regression analysis with restricted maximum likelihood.
A total of 5 cohorts from 4 studies were eligible for our analysis. FH patients had higher fIMT compared with controls [pooled MD 0.35 mm, 95% confidence interval 0.18 to 0.51 mm, P<0.001 (figure A)]. There was no correlation of each study's MD of IMT with age (P=0.83). In contrast, the difference of total cholesterol between FH patients and controls had a significant association with the MDs of femoral IMT (P=0.001, figure B).
FH is associated with a significant increase of femoral IMT, an index of subclinical atherosclerosis, compared to normolipidemic controls of similar age. The severity of FH expressed with the untreated cholesterol level is a determinant of the femoral artery wall thickness.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.–10:30 a.m.
Session Title: Markers to Assess Peripheral and Carotid Artery Disease: Rapid Advances
Abstract Category: 35. Vascular Medicine: Non Coronary Arterial Disease
Presentation Number: 1297–162
- 2013 American College of Cardiology Foundation