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The accurate diagnosis of acute myocardial infarction (acute-MI) is important to improve life prognosis. The ratio of brain natriuretic peptide (BNP) to troponin I (Tnl) level (BNP/Tnl-ratio) reflects the degree of left ventricular dysfunction and myocardial injury. We assessed the hypothesis that BNP/TnI-ratio is useful for discrimination between acute-MI and other disease.
Subjects were 719 consecutive patients who visited emergency department on ambulance because of chest symptoms from August 2010 to December 2011. Five-hundred and two patients were excluded by lack of data or out of detection limit of BNP or Tnl, and 217 patients were analyzed. The diagnosis of acute-MI was performed retrospectively after discharge by experienced cardiologists by using clinical records.
Twenty-eight patients were diagnosed as acute-MI. The patients with acute-MI presented significantly lower BNP/Tnl-ratio than the patients without acute-MI (P< 0.0001). The areas under the receiver-operating characteristics curves for the creatine kinase (CK), Tnl and BNP/Tnl-ratio to discriminate acute-MI were 0.695 (95%CI; 0.600-0.790, p=0.001), 0.759 (95%CI; 0.657-0.865, p<0.0001) and 0.892 (95%CI; 0.834-0.951, p<0.0001), respectively (Figure).
BNP/Tnl-ratio is a feasible and effective parameter to discriminate acute-MI. The predictive value of BNP/Tnl-ratio for acute-MI may be superior to other traditional biomarkers.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Cardiac Biomarkers and Cardiovascular Risk
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1303-209
- 2013 American College of Cardiology Foundation