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Timely detection of myocardial injury is essential for appropriate management of patients admitted to the emergency department. A novel ECG metric, “cardiac electrical biomarker” (CEB), employs eigenvalue modeling of the 12-lead ECG and quantifies dipolar vs. multipolar forces. We hypothesized that CEB correlates with high sensitivity troponin (HST).
We analyzed data of 130 consecutive patients, participants of a prospective cohort study, admitted to the emergency department (ED) to rule out acute myocardial infarction. Resting 12-lead ECG and HST were measured up to four 4 times, 3 hours apart. CEB was measured by the VectraplexECG System (VectraCor, Totowa, NJ). A multilevel mixed-effects linear regression model was used to account for correlations within the repeated measures of CEB and HST.
After exclusion of 5 subjects (noisy ECG), data of 125 patients (mean age 60.2±13.6 y; 52% male, 33% whites) have been analyzed. Overall 475 ECGs and 489 HST measurements were included in the analysis. CEB showed a strong, positive correlation with HST (r = 0.560; P=0.0007) [Figure 1]. In a mixed-effects linear regression after adjustment for age, race and gender, increasing CEB predicted HST elevation (beta-coefficient 0.64; 95%CI 0.32-0.95; p<0.0001).
A novel ECG parameter, “cardiac electrical biomarker”, strongly correlates with HST in patients, admitted to the ED to rule out acute myocardial injury. Further study of the cardiac electrical biomarker is warranted.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Cardiac Biomarkers and Cardiovascular Risk
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1303-210
- 2013 American College of Cardiology Foundation