Author + information
- John Terrovitis,
- Stefania Sventzouri,
- Lampros Katsaros,
- Vasilios Sousonis,
- Nickolaos Michelinakis,
- Chris Kapelios,
- Titika Sfakianaki,
- Argyrios Ntalianis,
- Apostolos Papalois and
- John Nanas
Inhibition of mitochondrial Na+/Ca2+ exchanger has been recently recognized as a novel therapeutic target for the prevention of arrhythmias in heart failure. We examined the effects of CGP-37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, administered at the onset of reperfusion, on infarct size and microvascular integrity in a porcine model of ischemia-reperfusion.
Acute myocardial infarction was induced in 18 pigs (weight 30–35kg) by ligation of the mid left anterior descending coronary artery for 60 minutes, followed by 2 hours of reperfusion. At 60 minutes of ischemia and before the onset of reperfusion, the animals were randomly assigned (1-1) to either intracoronary infusion of CGP or normal saline. At the end of the experiment, the infarct size (as a percentage of the myocardial area at risk) as well as the area of the hemorrhagic infarct were measured.
The myocardial area at risk was similar in both groups (28.82 ± 5.84 vs 28.12± 8.1, P=0.838 respectively). Infarct size did not differ between treated and control animal (74.94 ± 13% vs 79.45± 9.9% respectively, P = 0.42). There was a reduction of the hemorrhagic infarct in CGP treated animals, however the difference did not reach statistical significance (7.46 ± 6.2% vs 17.3± 18.9%, respectively, P = 0.17). ST resolution was faster in CGP-37157 treated animals (complete resolution within 30 minutes in 100% vs 0% in control animals).
In a preclinical model of acute myocardial infarction, intracoronary administration of CGP-37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, did not confer any cardioprotective effect in terms of infarct size reduction; however it expedited ST resolution towards normal and showed a trend for reduction of hemorrhagic infarct.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Acute Coronary Syndromes: Basic I
Abstract Category: 2. Acute Coronary Syndromes: Basic
Presentation Number: 1127-190
- 2013 American College of Cardiology Foundation