Author + information
- Zacharias Mandalenakis,
- Henry Eriksson,
- Mikael Dellborg,
- Kenneth Caidahl,
- Lennart Welin,
- Kurt Svärdsudd,
- Saga Johansson,
- Georgios Lappas,
- Annika Rosengren and
- Per-Olof Hansson
The aim of our study was to evaluate the predictive value of Atrial Natriuretic Peptide (ANP) for Atrial Fibrillation (AF) in a male population-based study.
The study is a part of “The Study of Men Born in 1913”, a longitudinal prospective cohort study of men born in 1913 and living in the city of Gothenburg in Sweden. We studied a random-sampled population of 528 men who were 75 years old in 1988 and followed them up for 15 years with a re-examination in 1993 and by Swedish national hospital discharge register until the age of 90. Blood samples were collected from all 528 men in 1988 and plasma level of ANP was analysed by the Shionoria method. Hazard ratio was estimated by Cox regression.
Fourteen participants were excluded because of a prior diagnosis of AF. During follow-up, 110 men were diagnosed with AF of whom almost 60% hade lone AF. Elevated ANP levels were strongly associated with AF, hazard ratio 2.993 (p<0.0001).
The Study shows a significant correlation between elevated levels of ANP and development of AF in elderly men during a follow-up of 15 years.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Arrhythmias: AF/SVT II
Abstract Category: 4. Arrhythmias: AF/SVT
Presentation Number: 1107-56
- 2013 American College of Cardiology Foundation