Author + information
- Alexandre M. Beno,
- Girish Nadkarni,
- Chaithanya Pamidimukala,
- Manpreet singh Sabharwal,
- Shiv K. Agarwal,
- Vijay Lapsia,
- Urvi Pai,
- Mayra Rodriguez,
- Joseph Bastawrose,
- Shuaib Mohamed,
- Joshua Aziz,
- Eyal Herzog and
- Emad Aziz
Atrial fibrillation (AF) is 10 to 20-fold higher in patients with severe renal insufficiency (SRI) defined as an eGFR< 30 mL/ min/1.73m2. Both AF and SRI are related to increased mortality when compared to the general population.
ACAP-RACE is a prospective longitudinal registry that was established at our institution for the management of patients with AF looking at the therapies effect of and risk factors at long-term outcome. Our currents primary endpoint was to establish if ethnic differences had an impact on mortality at AF and SRI patients.
The cohort includes 1662 subjects, with 151 meeting criteria. Among these, males were 54%. The racial distribution was Blacks ((B) (55.7%), Whites (W) (19.5%), Hispanics (H) (16%) and others (8.8%). During the follow-up 58 patients (38%) died. W had a significantly higher mortality (76’ %) when compared to B (57%) or H (53%) [p<0.01]. Most deaths (52/58, 90%) occurred within 2 years of initial admission. Atime to event multivariate analysis demonstrated race as the primary variable of interest with W having 2.6 times risk of death as compared to B (HR 2.6; 95% CI95% 1.2-6.0; p<0.02). This persisted after adjusting for confounders as sex, age, DM, HTN and smoking.
Our study demonstrates that in our population caucasians with AF and SRI are at a higher risk for death independent of other risk factors. Our study though limited by sample size lays the groundwork for future studies to elucidate the factors responsible for this disparity.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Arrhythmias: AF/SVT V
Abstract Category: 4. Arrhythmias: AF/SVT
Presentation Number: 1189-36
- 2013 American College of Cardiology Foundation