Author + information
- Frederik Hendrik Verbrugge,
- Petra Nijst,
- Philip De Vusser,
- Hugo van Herendael,
- David Verhaert,
- Pieter Vandervoort,
- Matthias Dupont,
- Wilfried Mullens and
- Maximo Rivero-Ayerza
Subclinical atrial tachyarrhythmias without clinical atrial fibrillation (AF) occur frequently in patients with cardiac devices and are associated with an increased risk of ischemic stroke/systemic embolism. Whether they influence response to cardiac resynchronization therapy (CRT) is currently unknown.
Consecutive CRT patients without AF history (n=118) were followed prospectively. Subclinical atrial tachyarrhythmia was defined as a device[[Unable to Display Character: ‑]]registrated episode of atrial rate >190 bpm for >30 seconds. Clinical AF was defined as symptomatic AF that triggered electrical/medical cardioversion or a change in antiarrhythmic medication.
During follow[[Unable to Display Character: ‑]]up of 26±9 months, 39 patients (33%) had subclinical tachyarrhythmias, while 21 (18%) developed clinical AF. Both groups were more obese, but otherwise had similar baseline characteristics. Reverse remodeling was similar compared to patients without atrial arrhythmias. While clinical AF was associated with a HR (95%CI) of 2.43 (1.40-4.24) for all[[Unable to Display Character: ‑]]cause mortality or unplanned hospital admission, this correlation was not observed in patients with subclinical atrial tachyarrhythmia (P[[Unable to Display Character: ‑]]value=0.540). Subclinical tachyarrhythmia did not predict occurrence of clinical AF later on (P[[Unable to Display Character: ‑]]value=0.511).
Subclinical atrial tachyarrhythmias are frequent after CRT implantation, but do not impair reverse remodeling nor clinical outcome. Subclinical atrial tachyarrhythmia is not a predictor of clinical AF.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Arrhythmias: Devices II – Improving Outcomes in Patients with Implantable Devices: Tweaking the Well-Functioning Machine
Abstract Category: 8. Arrhythmias: Devices
Presentation Number: 1190-43
- 2013 American College of Cardiology Foundation