Author + information
- Sadip Pant,
- Abhishek Deshmukh,
- Kevin Hayes,
- Apurva O. Badheka,
- Kaustubh Dabhadkar,
- Tushar Tuliani and
- Hakan Paydak
It is now well established that females have higher preponderance for Takotsubo Cardiomyopathy (TTC). Whether the gender difference exists in various types of arrhythmias (malignant vs. non malignant) associated with this disease is unknown. The objective of our study was to investigate the gender differences in burden of arrhythmias in patients with TTC.
The Nationwide Inpatient Sample (NIS) discharge records were searched for TTC in the year 2008 using the 9th Revision of the International Classification of Diseases (ICD 9) code. A total of 6837 patients with diagnosis of TTC were identified, among which 28% had documented arrhythmias. Various arrhythmias including atrial fibrillation (AFib), atrial flutter (AFl), paroxysmal supraventricular tachycardia (PSVT), and ventricular fibrillation (VF) were identified with appropriate validated ICD 9 codes. IBM SPSS 21.0 was used for statistical analysis. The categorical data was analyzed using ⊠2 test. Continuous data were expressed using measures of central tendency and frequency distribution.
Among males, the common form of arrhythmias in the descending order of frequency was AFib (7.6%), VF (3.1%), PSVT (1.4%), AFl (0.7%). Similarly, in females the incidence of these arrhythmias was 12.1%, 1.5%, 1% and 1.2% respectively. Sudden cardiac arrest occurred in 3.76% in males and 2.53% in females. Among these arrhythmias, AFib was significantly more common in females compared to males with TTC (OR: 1.6, 95% CI: 1.2-2.1, p-value 0.001). In contrast, females were less likely to have ventricular fibrillation (OR: 0.5; 95% CI 0.3-0.8, p-value 0.003) and sudden cardiac arrest (OR: 0.7; 95% CI 0.4-1, p-value 0.05).
Hence, gender disparity prevails not only in incidence of TTC but also in occurrence of arrhythmias in patients with TTC. While TTC has been established as a disease mainly of females, life threatening arrhythmias like VF and sudden cardiac arrest are more common in males.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Arrhythmias: Sudden Cardiac Death – Mechanisms and Treatment Strategies
Abstract Category: 6. Arrhythmias: Other
Presentation Number: 1192-56
- 2013 American College of Cardiology Foundation