Author + information
- Ajay Vallakati,
- Madhu Reddy,
- Venkata Alla,
- Pramod Janga,
- Donita Atkins,
- Sudharani Bommana and
- Dhanunjaya Lakkireddy
Limited data suggests that females may have increased recurrence of atria fibrillation (AF) after AF ablation. We intended to confirm this by performing a meta-analysis of studies reporting gender specific outcomes after AF ablation.
A PubMed search with term “Atrial Fibrillation Ablation” identified 6730 studies of which 630 studies reported outcomes of AF ablation. Among these, 94 studies reported gender specific recurrence of AF. After excluding studies with <100 patients, <1 month blanking period, <12 month follow-up and common-population publications, we identified 18 unique studies which were included in the final analysis.
The cumulative population consisted of 8745 patients of which 1747 (20%) were females. The mean age of the population was 59 ±11 years with 1747 (20%) females and 59% had paroxysmal AF. Random effects analysis showed that females had a higher risk of AF recurrence (RR of 1.189; p=0.030). Fixed effects analysis showed a similar results (1.250; p<0.001). Heterogeneity statistics did not show any significant heterogeneity. Beggs and Eggers regression test did not reveal any significant publication bias. Exclusion sensitivity analysis maintained the significance in all but 4 studies in which there was a very strong trend in the same direction of the composite analysis.
Meta-analysis of studies reporting gender-specific outcomes after AF ablation reveals that females have a 19% increased recurrence of AF after AF ablation.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Arrhythmias: Atrial Physiology and Ablation of Atrial Arrhythmias
Abstract Category: 6. Arrhythmias: Other
Presentation Number: 1238-58
- 2013 American College of Cardiology Foundation