Author + information
- Noboru Oda,
- Yukiko Nakano,
- Yoshikazu Watanabe,
- Hiroki Ikenaga,
- Mai Fujiwara,
- Takehito Tokuyama,
- Hiroshi Kawazoe,
- Kenta Kajihara and
- Yasuki Kihara
The relationship between sleep-disordered breathing (SDB) and atrial fibrillation (AF) was investigated in patients with AF.
Forty-three patients with paroxysmal and persistent AF who had undergone ablations were divided into severe SDB (apnea-hypopnea index; AHI >20 events/hr, n = 12) and mild SDB (AHI <20, n = 31) groups using all-night portable polysomnography. We compared backgrounds, human atrial natriuretic peptide (hANP) levels, left atrial (LA) sizes using transthoracic echocardiography, LA appendage (LAA) sizes and flow velocities using transesophageal echocardiography, and magnitudes of LA a to y waves using transseptal catheterization.
Both groups showed similar backgrounds. The severe SDB group showed larger LA sizes, higher hANP levels, and lower LAA flow velocities than the mild SDB group (severe SDB group vs. mild SDB group; LA sizes: 43.9 ± 7.5 vs. 36.5 ± 7.0 mm, hANP: 91.9 ± 42.6 vs. 35.8 ± 20.9 pg/ml, LAA flow velocities: 34.2 ± 13.8 vs. 50.1 ± 20.9 cm/s, p < 0.05). Magnitudes of LA × and y waves in the severe SDB group were significantly higher than those in the mild SDB group (9.0 ± 4.9 vs. 5.4 ± 3.9 mmHg and 9.0 ± 3.5 vs. 6.0 ± 3.5 mmHg, respectively).
Our results suggest that SDB raises minimum LA pressure, decreases LAA function and remodels LA, resulting in sustained AF.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Arrhythmias: AF/SVT X
Abstract Category: 4. Arrhythmias: AF/SVT
Presentation Number: 1279-43
- 2013 American College of Cardiology Foundation